While radical nephroureterectomy remains the gold standard for managing upper-tract urothelial cancer (UTUC), it is associated with major complications and loss of renal function. Nephron-sparing modalities are less invasive and offer an alternative approach for managing low-risk, lowgrade UTUC. In this video presentation, Dr Gary Steinberg addresses unmet needs in the management of UTUC and provides insights into choosing kidney-sparing approaches. New developments involving chemoablation for low-grade UTUC, and how these fit into the current treatment algorithm, are also discussed.
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